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Pain killer Tablets medications, also known as analgesics, are used to relieve pain caused by a variety of conditions, such as injury, surgery, headaches, or chronic illnesses. There are several types of pain killers, each suited to different levels and types of pain. Over-the-counter (OTC) painkillers like acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil) or aspirin are commonly used for mild to moderate pain. For more severe pain,