Orphenadrine (Norflex) Production Process

Orphenadrine (Norflex) is synthesized through a multi-step chemical process that involves the reaction of 2-methylbenzhydryl chloride with N,N-dimethylaminoethanol under controlled conditions. This reaction facilitates the formation of the orphenadrine base, which is then purified and converted into its salt form, commonly as orphenadrine citrate or hydrochloride, for pharmaceutical applications. The production process requires precise temperature and pH control to ensure high yield and purity. Stringent quality checks and regulatory compliance measures are undertaken throughout manufacturing to meet industry standards for safety and efficacy.